National Library of Medicine- Clinical Studies- Acupressure and Aromatherapy

Clinical studies, references can be located at the National Library of Medicine

AcuBracelet researches all current clinical studies, medical journals and reviews for accurate factual information.




The Efficacy of Acupressure for Symptom Management: A Systematic Review

Eun Jin Lee, PhD, RN, ARNP and Susan Frazier, PhD, RN


Exploratory analysis of the usefulness of acupressure bands when severe chemotherapy-related nausea is expected 

Joseph A Roscoe 1Pascal Jean-PierreGary R MorrowJane T HickokBrian IssellJames L WadeDavid K King


Acupressure bands are effective in reducing radiation therapy-related nausea

Joseph A Roscoe 1Peter BushunowPascal Jean-PierreCharles E HecklerJason Q PurnellLuke J PepponeYuhchyau ChenMarilyn N LingGary R Morrow


The Efficacy of Acupressure and Acustimulation Wrist Bands for the Relief of Chemotherapy-Induced Nausea and Vomiting: A University of Rochester Cancer Center Community Clinical Oncology Program Multicenter Study

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Joseph ARoscoePhDGary RMorrowPhD, MSJane THickokMD, MPHPeterBushunowMDH.IrvingPierceMDPatrick JFlynnMDJeffrey JKirshnerMDDennis FMooreJr.MDJames NAtkinsMD

Acupressure effect on sleep quality: A systematic review and meta-analysis

Alexander Waits 1You-Ren Tang 2Hao-Min Cheng 3Chen-Jei Tai 4Li-Yin Chien 5





Clinical Aromatherapy

Ashley J Farrar 1Francisca C Farrar 2



Clinical aromatherapy is an alternative medicine therapy that can be beneficial in the inpatient or outpatient setting for symptom management for pain, nausea, general well-being, anxiety, depression, stress, and insomnia. It is beneficial for preoperative anxiety, oncology, palliative care, hospice, and end of life.


The effect of inhalation aromatherapy with damask rose essence on pain intensity and anxiety in burned patients: A single-blind randomized clinical trial.

Sadeghi N, Azizi A, Asgari S, Mohammadi Y.Burns. 2020 Dec;46(8):1933-1941. doi: 10.1016/j.burns.2020.05.006. Epub 2020 May 19.PMID: 32507535 Clinical Trial.


The uses of aromatherapy in women's health

Jackie Tillett 1Diane Ames




Using therapeutic essential oils to support the management of anxiety

Lauren Mosshart Lowring 1


    1. Allard M., Katseres J. (2018). Using essential oils to enhance nursing practice and for self-care. The Nurse Practitioner, 43, 39–46.
    1. American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Arlington, VA: Author.
    1. Aprotosoaie A. C., Gille E., Trifan A., Luca V. S., Miron A. (2017). Essential oils of Lavandula genus: A systematic review of their chemistry. Phytochemistry Reviews, 16, 761–799.
    1. Aromatic Plant Research Center (2017). Unparalleled Analysis: GC-MS. Retrieved from
    1. Blissett K., Chima V., Lantz M. S. (2018). From stress to serenity: The use of aromatherapy to engage patients in care. The American Journal of Geriatric Psychiatry, 26, S119.



Aromatherapy and essential oils : a map of the evidence

Freeman, Michele, active 2010 author.; Ayers, Chelsea, author.; Peterson, Carolyn, PhD, author.; Kansagara, Devan, author.; United States. Department of Veterans Affairs. Health Services Research and Development Service. issuing body.; Portland VA Medical Center. Evidence-based Synthesis Program Center. author.

Washington, D.C. : Department of Veterans Affairs, Health Services Research & Development Service; September 2019

Library Catalog ; MMS ID 9917614753406676; NLM ID 101761475


BACKGROUND: The purpose of this review is to provide the Veterans Health Administration (VHA) with a broad overview of the effectiveness of aromatherapy and essential oils (EOs), and the health conditions for which these interventions have been examined. DATA SOURCES AND STUDY SELECTION: We searched multiple databases through February 2019 for systematic reviews (SRs) of aromatherapy and EOs for health conditions. Using pre-specified inclusion criteria, all abstracts and full-text articles were dual-screened for inclusion. When there were several qualified reviews for the same health condition, we selected a single review based on its recency, methods, scope, and applicability. DATA ABSTRACTION: From each review, we abstracted the focus of the SR, the number of controlled trials included, combined number of participants, duration of trials, condition treated, and relevant findings from controlled trials. We abstracted separate data for each of 5 outcome categories: psychological outcomes, nausea/vomiting, pain and other physical outcomes, sleep outcomes, and global health outcomes. DATA SYNTHESIS: For each review and outcome category we assigned values representing the effectiveness level of the intervention and confidence in the evidence and used these values to generate evidence maps. Additionally, we provide a narrative synthesis of the findings. RESULTS: We included 26 SRs representing the most recent and comprehensive evidence available. There is moderate-confidence evidence that aromatherapy is beneficial for pain in dysmenorrhea. Aromatherapy is potentially effective for pain in labor/childbirth; blood pressure reduction in hypertension; stress, depression, and sleep in hemodialysis patients; stress in healthy adults; anxiety in perioperative patients; and sleep quality in various populations, with low to moderate confidence in the evidence. For EOs applied topically, there is moderate confidence in the potentially positive effect of tea tree oil for tinea pedis. There is insufficient evidence of efficacy for all other conditions examined.